Prey for Rock & Roll is set in the Los Angeles club scene of the late 1980s and follows the story of Jacki (Gershon) and her all-girl punk rock band, Clam Dandy. On the verge of turning 40, Jacki decides that if the band's one last shot at the big time is unsuccessful, she will give up her dreams of stardom. Along the way, the women are rocked by personal tragedies that threaten to break up the band before they can get their last shot at success.